Evaluaión del efecto Hipoglicemiante del extracto de hojas de Chapuca o Uvilla silvestre (Physalis peruviana) en ratas (Rattus norvegicus) con Hiperglicemia inducida.

Abstract

A pharmacognostic and pharmacological study of Physalis peruviana (Uvilla sylvestre) was developed to evaluate its hypoglycemic effect when administered to albino rats (Rattus norvegicus) after the induction of hyperglycemia with 2 g / kg of soluble starch. For the development of the research, 3 extracts of Physalis peruviana, made with solvents of increasing polarity (diethyl ether, 70% alcohol and water) were used, which were administered in twenty-four albino rats 290 ± 50 g and randomly distributed in 8 Lots of 3 rats per group, represented as batches: white, problem, positive and 5 treatments; Administering to: white lot only the vehicle (water: tween 80 (1%)); Lot problem, starch 2g / kg; Positive batch, starch 2 g / kg and Glibenclamide 0.2 mg / kg; While the batch with hyperglycemia under treatment was administered with 0.86 (30%), 1.85 (60%) and 2.46 (90%) mg / kg body weight of Physalis peruviana extract. The glycemia was evaluated at 0, 30, 90, 150, 210 and 270 minutes after administration of the inducing substance. Statistically, Physali peruvian did not present an evident pharmacological action when using Glibenclamide 5mg as a reference drug. In addition, the toxicological study showed levels of acute toxicity absent. In conclusion, the doses given did not show any hypoglycemic effect when administered in rats with transient hyperglycemia. It is recommended to test the same study in related pathologies, but with tors experimental models since especially Solanceae family report pharmacological activity.