Validación de la actividad Gastroprotectora de Polypodium Calaguala, Buddleja Globosa y Piper carpunya ruiz & PAV en ratones con lesiones gástricas inducidas.

Abstract

A ssessment calaguala plants ( Polypodium calaguala ) guaviduca ( Piper carpunya Ruiz & Pav . ) a nd matico ( Buddleja globosa ) ( Mus musculus ) was performed on albino mice with gastric lesions induced by aspirin obtained from the Bioterio 's career biochemistry and Pharmacy - ESPOCH , seeking to determine the ability to remedy the gastric lesions and their potential effect gastroprotective . Extracts of plants selected from the leaves using a water - alcohol mixture and proceeded to make three mixtures distributed accord ing to the following ratios were prepared: calaguala - guaviduca - matico ( 30:30:40, w / w ) ; calaguala - guaviduca - matico ( 30:40:30, w / w) , and calaguala - guaviduca - matico ( 40:30:30, w / w) . T o prove the gastroprotective activity of mixtures , we proceeded to deliver the extracts described above orally using a cannula. Was used as positive control omeprazole 40mg/kg. To evaluate the gastroprotective activity was necessary to calculate the percent inhibition of stomach lesions for each of the test groups and the positive control group. The following results were obtained : calaguala , and matico guaviduca ( 40:30:30, w / w) and calaguala , and matico guaviduca ( 30:30:40, w / w ) have a 95.83 % inhibition of the gastric lesions . While the ( +) control and calaguala , and matico guaviduca ( 30:40:30, w / w ) exhibit a percentage inhibition of the gastric lesions of guaranteeing absolute 100% recovery within this experimental model. It is advisable to continue this research gastroprotective activity of these vegetables using more extensive testing in living systems more complex following the protocols established experimental research.