Formulación y elaboración de un comprimido con actividad antidiabética a base de Justicia chlorostachya Leonard

Abstract

The present work, formulation and elaboration of a tablet with antidiabetic activity based on Justicia chlorostachya leonard", carried out at the School of Biochemistry of ESPOCH and at the Faculty of Sciences of the Central University of Ecuador, was carried out in the School of Biochemistry of ESPOCH and at the Faculty of Sciences of the Central University of Ecuador. With the application of the Analytical-Experimental method, a vegetable extract (Insulin) was used with a concentration of 0. 09mg of fluid/compressed extract, excipients, tableting machine, hardness tester, analytical balance, disintegrator, friabilizer, dissolver; applying different techniques such as: physicochemical determinations, bromatological composition, compression by wet granulation, developing three formulations to use different supports: dicalcium phosphate (Formulation 1), starch-lactose 50/25 (Formulation 2), starch-lactose 25/50 (Formulation 3). Obtaining as results tablets that meet pharmacotechnical parameters: mass uniformity, resistance F1 6.12kgf / F2 6.53kgf / F3 6.65kgf, friability F1 0.93% / F2 0.68% / F3 0.74% , disintegration F1 15.5min / F2 12. 8min / F3 5.2min, the microbiological analysis showed absence of mesophilic aerobes, absence of yeast molds, absence of total and fecal coliforms, indicating absence of hygienic and manufacturing contamination. The flavonic release determined different behaviors, Formulation 1 does not reach 60% being unfavorable, Formulations 2 and 3 show a favorable behavior releasing 95 and 100% of the active principle. It is recommended to the student sector to carry out studies of other pharmacological activities derived from the present work linked to the richness of phenolic compounds of Insulin, which contribute to improve the lifestyle of the diabetic patient.