Elaboración y Control de Calidad de Tintura y Gel Cicatrizante y Antiinflamatorio de Chilca (Baccharis latifolia) y Hierbamora (Solanum nigrum)

Abstract

A gel for topical use based on chilca (B. latifolia) and hierbamora (S. nigrum) was prepared and compared with diclofenac as a reference to test the anti-inflammatory effect. The active principles of the extracts have been identified by phytochemical screening, thin layer chromatography and spectrophotometry, in the preparation of the gel fluid extracts were used, for the tincture hydroalcoholic extracts were used at 40%, both products packaged in plastic containers with lids, the gel does not present lumps, it is homogeneous with a viscosity of 54. 60 centipoins, extensibility of 4.36cm; the dye has a pH of 5.60 and relative density of 0.97g/L, the microbiological analysis of the products showed absence of contaminating microorganisms. To verify the efficacy of the gel in Wistar rats, the method used was the induction of plantar edema with carrageenan at 2% versus a control group with application of chilca extract gel (T2), blackberry extract gel (T3) and gel of the mixture of extracts (T4), the concentration of the gel and diclofenac gel is 1% (T1). The inflammation in rats with the application of the gel was obtained that at 1 hour, with T2 is 3.63cm, with T3 is 3.47cm, with T4 is 3.40cm compared to T1 is 3.33cm. With the application of the gel in patients we have that at 1 hour with T2 it is 38.32cm, with T3 it is 38.33cm, with T4 it is 39.33cm compared to T1 it is 40.33cm. It is proved that the mixture of extracts decreases inflammation, as with diclofenac. The extract mixture gel decreased inflammation in both rats and patients. Studies on the alkaloids of the herbamora should be carried out and another pharmaceutical form should be elaborated where the flavonoids of the chilca are potentiated.