Formulación de un protector solar a base de Oreocallis grandiflora.

Abstract

The main objective of this work was to formulate a sunscreen based on Oreocallis grandiflora. To this end, the collection, conditioning and quality control of the vegetable drug was carried out, after which, through the phytochemical screening, the secondary metabolites present in the plant species were evaluated qualitatively, denoting appreciable amounts of phenolic compounds. The hydroalcoholic extract of the leaves of Oreocallis grandiflora was obtained and it was concentrated in the rotavapor until obtaining the dry extract. Through spectrophotometry, the concentrations of phenols and flavonoids were quantified, obtaining results of 208.33 ± 12.58 mg/g and 286.29 ± 7.39 mg/g of plant, respectively. The high values of the mentioned metabolites could be responsible for the photoprotective activity against harmful UV radiation. According to the methodology described by Mansur, the solar protection factor (SPF) was determined in vitro with a result of 48 789 at a concentration of 3000 ppm of dry extract of Oreocallis grandiflora. Subsequently, the photoprotector formulations were made, in which the amount of emulsifiers was varied in order to evaluate if the SPF could vary depending on that change, so that the formulations with the highest amount of lecithin presented a better performance, Likewise, the organoleptic, physical, chemical and microbiological characteristics of the photoprotectors were estimated in order to highlight the best formulation. Finally, the packaging and labeling was carried out under the NTE INEN 2867 standards to provide the product information to the consumer. Therefore, formulation 2 was selected as ideal since it has pleasant sensory characteristics, optimum pH, is safe, adequate extensibility and high SPF. It is recommended to carry out product stability tests to determine the period of time and storage conditions in which the safety, quality and safety specifications are conserved.