Estudio fitoquímico preliminar y evaluación de la actividad citotóxica del látex de Euphorbia laurifolia Juss. Ex. lam sobre Artemia salina.

Abstract

Euphorbia laurifolia is a plant species that belongs to the family Euphorbiaceae located in colombia, venezuela and Ecuador. traditionally, it is used for liver affections and to avoid the formation of skin abscesses and warts. Due to its high availability and variety of uses, it has phytochemical and pharmacological importance. the aim of this investigation was to carry out preliminary phytochemical study and evaluation of the cytotoxic activity of E. laurifolia latex on artemia salina. several latex extracts, separation and identification of compounds was performed by Thin Layer Chromatography (TLC). The evaluation of the cytotoxic activity on artemia Salina was carried out using the hexanic fraction at concentrations of 0, 31, 62, 125, 250, 500, 1000 ppm. it was established that E. laurifolia contains terpene compounds, identified by TLC molecules such as borneol (Rf 0.24) and cineole (Rf 0.40). Regarding the cytotoxicity of the hexane fraction, the lethal concentration (lc50) was 214.50 ppm, showing that the extract is toxic. the latex of E. laurifolia is rich in terpene compounds with high cytotoxic activity; therefore, it presents a remarkable potential for future pharmacological studies.