Estudio comparativo de la actividad psicoactiva de Passifloras de la provincia de Chimborazo.

Abstract

Climate variability and territorial location of Ecuador promotes biodiversity in the country. However, due to the presence of a big number of flora and fauna per square kilometer, most of it is not studied and despite not having a scientific argument for the use of some species, the population uses many of these for different pathologies, for this reason, a pharmacological study of six species of the genus Passiflora from the province of Chimborazo – Ecuador was carried out, traditionally used to treat nervousness. For identification, a thin layer chromatography profile of each species was carried out, of which it was possible to determine considerable quantities of molecules with grouping of flavonoid type and quantification of the total flavonoids. Of all the species P. manicata was noted for its high content of total flavonoids using aluminum chloride method for derivatizing the compounds of interest and to evaluate UV-visible spectrophotometry. While for the pharmacological activity it was carried out in vivo by the elevated plus-maze test. From the results obtained it has been determined that at least two of the six species have significant anxiolytic activity at doses of 25 and 50 mg/kg of hydroalcoholic extract. Species like P. edulis and P. mixta have bioactive constituents for this purpose.