Estudio cinético de liberación de quercetina a partir de microcápsulas por el método de difusión por diálisis.

Abstract

The aim of this work was to determine the kinetic model which the quercetin microcapsules obtained in ionic gelation are adapted, to quantify this drugs dissolution using spectrophotometry and to check if there is a difference when releasing the drug modifying pH of the microcapsule solvent using dialysis. Quercetin is a flavonoid that is known due to its high antioxidant capacity. Besides, it is susceptible to weather conditions, such as light and temperature and is degradable under acid pH conditions. The most important thing is that it protects itself and is well absorbed by intestines due to its alkaline pH which wont affects its function. It was possible to determine that there is difference in the percentage of quercetin release if the pH value of the microcapsule solvent increase. The pH value is 8. The Ideal percentage for the maximun quercetin reléase is 92.59%. Hixson-Crowell was the best kinetic model in which microcapsule are adapted, that is why the quercetin is release by matrix erosion known as abnormal release process. It is recommended to follow up the morphology studies of microcapsules and their formulations modifying the polymer when used.