Evaluación de la actividad cicatrizante del extracto de hojas de tomate (Solanum Lycopersicum) en lesión, inducida en ratones (Mus Musculus).

Abstract

This research had as objective to evaluate the healing activity of the tomato leaves (Solanum lycopersicum) in lesions induced in mice (Mus musculus), executed in the Vivarium in the Faculty of Sciences of the Polytechnic School of Chimborazo. For the effect, it was used the extract of vegetal and 24 mice, assigned in 6 experimented groups that are: Group B (untreated), two groups positive control (C and D) treated with cream base of (Prednisolone Acetate 0,5g), and alcohol to 40% respectively and three experimental groups (X, Y and Z), which received the extract of the vegetal leaves to concentrations of 25%, 50% and 75%. In the quantification of secondary metabolites, it has shown the total flavonoid content equivalent to quercetin of 0.799 mg/g dry matter in the hidroalcoholic extract and of 2.93 mg/g dry matter in the ethanol extract; while the total phenols content equivalent to galic acid of 1.29 mg/g dry matter in the hidroalcoholic extract and of 3.44 mg/g dry matter in the ethanol extract. The treatment was applied topically every 12 hours for, every 15 days, the time of healing was measured and the length of the wound until the detachment of the crust, which the results were statistically analyzed by the Anova and Tukey test, with a confidence interval of 95%, it showed the effectiveness of the treatment applied. It concludes that treatment with extract to 75%, applied in induced injury provides more effective results, with healing in 7days average and extraordinary cellular regeneration in minor injuries, through the topically and no presents adverse reactions at cutaneous level. It is recommended to formulate a phytodrug, to facilitate the use of the extract of the Solanum lycopersicum leaves.