Evaluación de la Actividad Cicatrizante de extractos de hojas de Llantén de páramo (Plántago Australis) en lesiones, inducidas en ratones (Mus musculus).

Abstract

In this research the healing activity of extract from plaintain leaves (Plantago australis) in the moors was evaluated. Quality control of plant material and extracts were made giving as results density of 0,8296 g/mL, refractive index 1.344, pH 4,95 and 4,78% of total solids. The quantification of phenol and flavonoids was executed in hydroalcoholic and ethanolic extract giving as result sample total phenols revealed in gallic acide as 2,78 and 5,06 mg/g respectively, sample total flavonoids showed in quercetin was 1,52 and 2,35 mg/g respectively. Microbial quality of the extracts applied in mice injures was determined. That is why the obtained results had a good quality. In the healing effect evaluation was used 24 mice with induced lesions, the results obtained from days of healing were subjected to statistical analysis using XLSTAT software, with a confidence interval of 95%, thus was obtained as a result that the extract of 75% and 50% Plantago australis leaf present higher therapeutic effect as it healed wound at 7 and 8 days respectively, these results relate to a comercial drug prednisolone acetate 0,5 g and 0,5 g neomycin sulfate which presented scarring in 13 days, with 40% alcohol healed in 11 days and natural healing in 15 days. In the histopathological analysis the results showed good celular tissue regeneration. According to the results it concluded that have better effects treated lesión with 75% extract, and 50% less healing time and good cell regeneration. It recommeds producing a suitable dosage form of Plantago australis extract for a better medical managment.