Actividad hipoglucemiante del extracto Hidroalcoholico de Jungia rugosa en ratones (Mus musculus) diabéticos inducidos por estreptozotocina.

Abstract

The hypoglycemic effect of alcoholic extract of Jungia rugosa Less in mouse laboratory animal model (Mus musculus) strain BALB/c which diabetes, was induced by administration of streptozotocin was evaluated, nicotinamide and streptozotocin, after applying an experimental design randomized block, treatments to experimental groups at doses of 25mg/kg, 100mg/kg and 400mg/kg of hydroalcoholic extract per kilogram of animal weight were administered. Discriminating a positive advancing treatment without the presence of an active control was used. The extract was obtained by a reflow process from 40 grams of dried aerial parts of the plant species. It was achieved resulting in a marked in glycemic levels in the case of moderate diabetes during hours after to the treatment administration, and through the days established by the protocol. This fact was tested using analysis of variance (ANOVA) followed by DUNNET post-test. The treatments being 100mg/kg and 400mg/kg are the most effective. Treatment of 25 mg/kg compared with the control. As severe diabetes there was no significant difference between treatment and control. So, it is concluded that the treatments are as effective as the control. In addition, the toxic effect of Jungia rugosa Less at a dose of 2000mg/kg in a group previously set was analyzed. The result was conclusive that there was no toxic effect, which is demonstrated by the plant is safe for human consumption. It is recommended that the analysis of the aqueous fraction of the extract, since here may exist metabolites with similar effects. Also, it is necessary elucidate the specific structures of the compounds of the plant.