Estudio Bioquímico Clínico de la exposición a plaguicidas organofosforados y carbamatos sobre el perfil Hepático en agricultores de la parroquia de San Luís cantón Riobamba provincia de Chimborazo

Abstract

A Clinical biochemical study was performed from the organophosphates and carbamatos pesticides exposure about the hepatic profile on farmers from two communities (San Antonio and Tiazo) in San Luis Parishat Chimborazo province, in order to establish the al terations of values in the liver function and prevalence of clinical symptomatology into the body that affects by use of these pesticides. For this study is made a socialization in each community, a surve y and observation of the workplace was applied, the determinations were performed in 101 biological samples, 81 from farmers exposed to pesticides and carbamatos organophosphatesand 20 people nonfarm in the same area (not exposed). The evaluation of transaminases (ALT/ALT) was performed using kinetic method IFCC UV (ultra violet) without piridoxal phosphate, gamma - glutamyl transpeptidasa (GGT) according to the Glupa - C method, lactate dehydrogenase (LDH) UV kinetic method IFCC, total and direct bilirubin, Malloy - Evelyn method modified endpoint; and implementa tion of an individual structured questionnaire. The results considered an alteration in the experimental group, by gender men have the highest values (LDH 58%, 32% TGP, TGO 21%, GGT 19%, Total bilirubin 13% and direct B. 8%), according to the age ranges be tween 40 - 49 years old have the highest values (LDH 53%, 33% TGP, TGO 27%, GGT 17%, total B. 13% and direct B. 10%), according to symptomatology, the result show in general level: decay 61%; about the skin: rash 31%; at eye level: burning 49%; Respiratory S ystem: cough 28%; digestive system: nausea 23%; musculoskeletal: muscle weakness 58% and reproductive system: congenital defects 4%. So it concluded that the organophosphate and carbamatos pesticides affect the liver function values and the prevalence of c linical symptoms. Therefore it recommended developing training activities and regular control of liver function markers.