Comparación del efecto cicatrizante de las tinturas elaboradas a base de matico (Eupatorium glutinosum) y acíbar de sábila (Aloe barbadensis) aplicado en ratones (Mus musculus)

Abstract

The healing activity of extracts of Aloe ( Aloe barbadensis ) and Matico ( Eupatorium glutinosum ) in mice ( Mus musculus ) i n the Vivarium of the Sciencie Faculty of the Polytechnic School o f Chimborazo was evaluated. Previ o us to the comparison in vivo, a quality control of the raw m aterials was made, as a result of it could determine that it was within the parameters established by international standar d s. Dyed in Aloe and Matico were prepared by maceration with 40% alcohol, 3 mixtures of dyes prepared in different proportions 70:30, 30:70 and 50:50; it was made organoleptic, physical - chemical controls, microbiological and determination of its components by thin layer chromatography. By inducing wound on the back of 24 mice divided into 8 groups research the healing activity was evalu ated treatments being investigated: G1 (control +) = Treaty Eterol, G2(control +) = Treaty Cream Lamoderm, G4 = Treated with aloe extract, G5 = Treaty Matico extract, G6, G7 and G8 (dosages) = treaties with the mixture of the above extracts, administered topically until healing is complete. Statistical analysis of the results with a confidence interval of 95% was made, it was concluded that all extracts have effective healing activity and are statistically different, reducing healing time, these extract gr oup G6 (70% aloe dyeing and 30% Matico dyeing) completed healing a period of 8,33 days due to the presence of anthraquinone compounds in the bitterness and the Matico flavonoids exhibit synergy when combined. It is recommended that studies of long - term sta bility of the dyes.