Evaluación de la actividad expectorante de Molle (schinus molle l.), Iso (dalea coerulea), Jacaranda (jacaranda mimosifolia), Jengibre (zingiber officinale), Romero (rosmarinus officinalis), Marrubio (marrubium vulgare), en ratones (mus musculus)

Abstract

The determination of the expectorant activity was performed on the alcoholic extracts of six plants; Molle (Schinus molle L.), Iso (Dalea coreulea), Jacaranda (Jacaranda mimosifolia), Ginger (Zingiber officinale), Rosemary (Rosmarinus officinalis), Marrubio (Marrubium vulgare). Phenol red was the substance used as reference in the pharmacological assay; to find colorimetrically the phenol red concentration in the tracheobronchial secretions of mice (Mus musculus), a solution of phenol red (20mg ml) was prepared and administered to the mice (Mus musculus) intraperitoneally, followed by the extract of each plant orally. After thirty minutes the tracheas were extracted and washed for five minutes with physiological saline and sodium hydroxide (NaOH 1N) in proportions (1:9). The samples were immediately taken to UV for reading at a wavelength of 560 nm, using sodium hydroxide (NaOH 1N) as a blank. The concentration of phenol red found in the tracheobronchial secretion with Bromhexine was 0.86 mg/mL of phenol red; while that of the alcoholic extracts of the plants studied were Rosemary (Rosmarinus officinalis), 0.65 mg/mL, Horehound (Marrubium vulgare) 0.41 mg/mL, Ginger (Zingiber officinale), 0.63 mg/mL, Iso (Dalea coerulea), 0.40 mg/mL, Molle (Molle), 0. 40 mg/mL, the Molle (Schinus molle L.), 0.38 mg/mL and Jacaranda (Jacaranda mimosifolia), 0. 240 mg/mL of phenol red in tracheobronchial secretions of mice (Mus musculus)Anova and Tukey statistical analysis determined that Rosemary (Rosmarinus officinalis), Ginger (Zingiber officinale), have expectorant activity; while Horehound (Marrubium vulgare),Iso(Dalea coerulea), Molle (Schinus molle L. ), and Jacaranda (Jacaranda mimosifolia), lack expectorant activity. Rosemary (Rosmarinus officinalis) and ginger (Zingiber officinale) extracts can be used as expectorants in the pharmaceutical industry. It is recommended to study the above mentioned extracts, using different concentrations, in order to obtain better results.