Implementación de un Sistema de Farmacovigilancia para el Uso Seguro de Medicamentos, en Consulta Externa de Gastroenterología de la Unidad Oncológica SOLCA Chimborazo

Abstract

Objective: To implement a pharmacovigilance system for the safe use of drugs in the gastroenterology outpatient area of the SOLCA Chimborazo Oncology Unit. The population consisted of one hundred and eighty-eight (188) patients, with a sample of 44.7% (84 patients), including patients with adverse reactions to medications. The technique used was observation through the use of voluntary and intensive notification pharmacovigilance techniques, for which notification forms and medication forms were used, which were filled out during the medical consultation, personal interview with the patient, telephone calls and visits to the patient's home. In the comparison of averages obtained, an ANOVA analysis of variance was performed, showing that the mean of adverse drug reactions corresponding to the months of June, July and August 2010, had a significant difference. In the 5% modified Tukey test, it was observed that sedatives are statistically different from other pharmacological groups presented in the same statistical group. It is concluded that the pharmacovigilandia system progressed month by month while it was implemented, allowing the collection and recording of data on ADRs that were not available, which makes it possible to foresee them and give pertinent indications, contributing to the patient's lifestyle not being modified surprisingly, with special attention to sedatives (Midazolam) since they are the drugs with the highest reports of adverse reactions to them during the evaluation period. Therefore, the implementation of a pharmacovigilance system in the different areas of the SOLCA Chimborazo Oncology Unit is recommended, especially in the chemotherapy area, since the drugs used in this area cause a large number of adverse reactions that are not reported.