Comprobación del efecto cicatrizante de los extractos hidroalcohólicos de malva (Malva sylvestris L.) y aguacate (P. americana) en ratones (Mus muscullus)

Abstract

In the present investigation, the healing activity of Malva (Malva sylvestris L.) and Avocado (Persea americana) leaves was evaluated in the Biotherium of the Faculty of Sciences of the Polytechnic School of Chimborazo. The method used is the experimental method and the materials used are hydroalcoholic extracts, reagents, experimental animals 18 mice of the species (Mus musculus), a wound induction was performed in an area of 2cm x 3mm deep, which includes skin and subcutaneous cellular tissue. For this research, 6 treatments were performed, of which B= untreated wounded mice, C= wounded mice treated with Eterol, H, I, J, K, dosages = treated with mallow and avocado extract with individual concentrations H, K (100%) and I, J with a mixture of the same (65:35, 35:65), administered topically with sterile swabs and a daily application for a period of 12 days, the size of the wound was measured until the detachment of the scab. The results were subjected to a statistical analysis using the G-STAD program, with a confidence interval of 95%, it was obtained as a result that the mallow and avocado extract in a dosage proportion of 65: 35 possess effective healing activity in a period of 7 days due to the presence of flavonoids and tannins in the mallow and in the avocado tannins, which when combined present synergy, these parameters were related to the activity of the Eterol which presented in 8 days the healing of the wound, comparing also with the natural healing which was presented in 12 days. It is concluded that the hydroalcoholic extracts of Malva (Malva sylvestris L.) and Avocado (Persea americana) have healing activity in minor cutaneous wounds and when applied topically to the experimental groups they do not present adverse effects at cutaneous level.