Comprobación del efecto cicatrizante de los extractos hidroalcohólicos de dos variedades de escancel (Aerva sanguinolenta de Pastaza y de Chimborazo aplicados en ratones (Mus musculus)

Abstract

This research aims to test the healing activity of the two varieties of Escancel (Aerva sanguinolenta) of Chimborazo and Pastaza in mice of the species Mus musculus, this study was conducted in the laboratories of phytochemistry and the biotherium of the Faculty of Sciences of the Polytechnic School of Chimborazo. The research method applied was the experimental method, the materials used are hydroalcoholic extracts, reagents, and experimental animals, 18 mice were used to induce the wound, which was 2 cm long and 0.2 cm deep. For the subsequent application of the 8 treatments, these being: C (Control +) =Treated with Eterol, B(Control-) = without treatment; groups X,Y,Z;A,D,E with dosages (100%,50%,10%;100%,50%,10%)= Treated with the extract of Escancel de Chimborazo and Pastaza, administered topically with sterile swabs and 1 application every day for the lapse of 14 days, monitoring the infection by observation. For the statistical analysis the statistical program G-STAD was applied, with a confidence interval of 95%, it was obtained as a result that the extract with a concentration of 100% Escancel de Chimborazo is the one that has greater effect healing the wound in less time as in 8 days, these parameters were related to the activity of Eterol which presented the wound healing at 8 days, it was also compared with the natural healing that was presented at 14 days. It is concluded that the hydroalcoholic extracts of Escancel de Chimborazo and Pastaza have healing activity in skin wounds affirming that when applied topically they do not present adverse effects at cutaneous level. It is recommended to elaborate a phytopharmaceutical with the dosage of treatment X for an easy topical administration.