Evaluación del efecto ansiolítico del extracto hidroalcohólico de flor de taxo (Passiflora tripartita var. Mollissima) en ratones (Mus musculus)

Abstract

The research is to verify the anxiolytic effect of the hydroalcoholic extract of Taxo flower (Passiflora tripartita var. Mollissima) in mice (Mus musculus), was carried out in the Biotherium of the School of Biochemistry and Pharmacy of the Polytechnic School of Chimborazo. By means of the Experimental Method, psycholeptic tests (Central Nervous System depressors) were carried out in order to check if the taxo flower extract presents the desired anxiolytic effect. Eighteen mice were divided into six equal groups called: A (White); B (Chemical positive control); C (Natural positive control); D (Experimental group 1); E (Experimental group 2); F (Experimental group 3), which received Taxo flower extract, at concentrations of 40%; 70%; 100%, respectively. Group B received Diazepam, group C received Passiflora edulis, group A received propylene glycol as vehicle. For data analysis, ANOVA (analysis of variance) and Tuckey 95% confidence tests were used. After applying different treatments of the hydroalcoholic extract of Taxo flower (Passiflora tripartita var. Mollissima), anxiolytic activity was found in the concentrations administered, with the 100% concentration being more effective. It was concluded that this Taxo flower extract, as an anxiolytic, is experimentally proved with the present study, being the secondary metabolites flavonoids and alkaloids responsible for such pharmacological activity. I recommend to students and teachers that based on this research, new studies on plants used for anxiety disorders should be carried out, contributing to improve the lifestyle and quality of life of people suffering from this disease.