Formulación de un gel cosmecéutico antiacné a base de extracto de flores de caléndula (Caléndula officinalis) y propóleo

Abstract

An anti-acne cosmetic gel based on Calendula (Calendula officinalis) flower extract and Propolis was formulated in the CITEFARM pilot laboratory of the Faculty of Sciences of the Polytechnic School of Chimborazo. Effect previously evaluated in vitro by experimental method with standardized extracts of calendula flowers (Calendula officinalis) and Propolis, active microbicide substances that prevent the proliferation of opportunistic bacteria that cause the clinical picture of acne. Different concentrations of gelling agent were used to formulate the gel. The amounts of the extracts and the other cosmetic ingredients: humectants, depigmenting agents, antioxidants and preservatives were kept constant. Four gel formulations were made and physicochemical, organoleptic and microbiological characteristics were determined in each one based on the Brazilian ANVISA 2005 standard and the Panamanian GO 2134-2001 standard. Formulation F2 presented the following parameters: slightly fluid gel, transparent, yellow in color, with homogeneous consistency. With a pH of 6.9; viscosity index of 9945 centipoin (cp); relative density of 1.030; extensibility index of 10888.5 square millimeters (mm2); and 17.14 % of volatile materials. These parameters allowed us to determine that the F2 formulation is the most stable and presents the best organoleptic characteristics for the customer. It is recommended to evaluate the efficacy of this formulation in humans instrumentally and in vivo to complete this research.