Control de calidad de comprimidos elaborados con extractor de alcachofa (Cynara scolymus) y romero (Rosmarinus officinalis) para Neo-Farmaco

Abstract

The elaboration of slimming tablets in the Neo-Pharmaceutical Industry located in the city of Ambato and the Faculty of Sciences, ESPOCH. The extract was obtained by maceration and elimination of the solvent. The artichoke (Cynara scolymus) and rosemary (Rosmarinus officinalis) extracts have pH 5.83 and 5.93, refractive index 1.383 and 1.331, relative density 0.876 g/mL and 0.842 g/mL, total solids 4.3% and 6.3%, respectively. Microbiological analysis showed the absence of microorganisms. Phytochemical screening indicates in artichoke the presence of sesquiterpene lactones, saponins, bitter principles, phenols, phenolic acids; in rosemary there are phenolic derivatives, saponins, essential oils and resins. The tablet formulation contains 4.3% artichoke extract, 6.3% rosemary, 30% corn starch, 25% lactose monohydrate, 7% starch 1500, PVP 5%, Mg stereate 2%, talc 1%, starch glycolate 19.5%, manufactured by wet granulation. Tablets are round biconvex, smooth, slightly yellow, with aromatic odor and bitter taste. Weight 402 mg, thickness 5.07 mm, diameter 10.26 mm, hardness 10.12 kgf, disintegration 6 min, friability 0.17%, absence of microorganisms. It is concluded that after the analysis the values obtained are within the specifications of the Spanish Pharmacopoeia. The biological activity of slimming action was proved in mice with a weight reduction of 18.8%. The chemical marker of artichoke is cynaropicrin and rosemary is rosmarinic acid present in the vegetable and in the tablets. It is recommended that the tablets should be administered after meals due to their bitter taste and may damage the gastric mucosa.