Evaluación del efecto antiinflamatorio de los extractos (Miconia pseudocentrophora, Brachyotum ledifolium, Fuchsia loxensis) en ratas (Rattus novergicus)

Abstract

The investigation of the evaluation of the anti-inflammatory effect (Miconia pseudocentrophora, Brachyotum ledifolium, Fuchsia loxensis) in Rattus novergicus, was carried out in the Biotherium, Laboratory of Phytochemistry - Faculty of Sciences - ESPOCH. The taxonomic identification was made in the herbarium; the methodology used in the preparation of extracts was first by maceration of the fresh plant with concentrated ethanol at 1/8 of the refrigerated volume, the sub extracts obtained by extraction with chloroform, eliminated the solvent, the residues obtained were analyzed for physical and chemical properties, the oral application to Rattus Novergicus in six batches in triplicate for each plant, prior to the induction of plant edema by Carrageenan 0.5%, the decrease of the plant measure in cm2 indicates effectiveness. The results obtained are: Llumbre corresponding: Brachiotumledifolium, moisture 49%; Ash 4.07; Yield Extract 78.6%; transparent liquid; herbal yellowish green; slightly sweet; pH 14.18; Refractive index 1.355, Density 0.91 g/mL; metabolites, Flavonoids, alkaloids, quinones, triterpenes; anti-inflammatory activity 39.27%. Fuchsia loxensis moisture 79.48; Ash 3.70; Yield extract 89.2%; liquid slightly turbid; yellowish brown; characteristic sweet, pH 4.18, I. refraction 1.35; Relative density 0.75 g/mL metabolites, Flavonoids, alkaloids, quinones, triterpenes. Anti-inflammatory activity 43.59%. Miconia pseudocentrophora Moisture 48%; Ash 2.91; extract yield 97.5%; cloudy liquid; brown, sweetening, bitter; pH 3.60; r. index 1.363; Relative density 0.97 g/mL; metabolites, Flavonoids, alkaloids, quinones, triterpenes. Anti-inflammatory activity, 54.07%. Brachiotum chloroplast extract with activity of 52.85%; Miconia 54.07%, Fuchsia 52.41%. The results of anti-inflammatory activity are for the Miconia subextract.