Elaboración de un Fitofármaco Sólido con Propiedades Adelgazantes Preparado en Diferentes Dosis a base de Alcachofa (Cynara cardunculus var scolymus), Jenjibre (Singiber officinale) y Apio (Apium graveolens) Administrado a Personas para Comparar su Eficacia

Abstract

A solid phytopharmaceutical was elaborated with extracts of Artichoke (Cynara cardunculus var scolymus), ginger (Zingiber officinale) and celery (Apium graveolens), in the laboratory of Phytochemistry of the Faculty of Sciences of ESPOCH, through experimental design and the technique of wet granulation of a batch of 500g, a concentration equivalent to 1. 6 g of p.a. in the case of the minimum concentration and an equivalent of 3.2 g of p.a. for the maximum concentration, together with PVP 3% to form the mucilage and incorporate it to the other excipients dicalcium phosphate 73%, microcrystalline cellulose 23% and magnesium stearate 1%, to then compress in the Stokes tabletting machine. Tablets were obtained with a flat round appearance, smooth faces, olive green color, spicy flavor and aromatic odor, average weights of 600 mg, thickness 8.71, hardness 7.4 Kgf, friability 0.04 % and disintegration 20.54 minutes, which were found to be within the physical, chemical and microbiological specifications. The tablets provided a better way to orally administer the plant extracts due to a better presentation and accuracy in the doses. The test was carried out randomly in 4 groups of men and women between 22 - 65 years of age, with a dose of 3 tablets daily. The results at the end of 15 days of treatment were the slimming effectiveness of the tablets of higher concentration administered to the volunteers who did not alter their diet or daily rhythm of life and did not present any side effects throughout the treatment. A long-term stability study is recommended to know the shelf life of the tablets.