Evaluación de la Actividad Hipoglucemiante del Extracto Acuoso de Semillas de Alpiste (Phalaris canariensis) en Ratones (Mus Muscullus) con Hiperglicemia Inducida

Abstract

To evaluate the hypoglycemic effect of canaryseed (Phalaris canariensis) in mice (Mus musculus) with hyperglycemia induced by sucrose overload, this study was conducted in the biotherium of the Faculty of Sciences of the ESPOCH. The experimental method was used, for which 18 mice were divided into 6 groups of 3 animals each one named: T1, T2, T3 (100%, 70% and 30% doses of canaryseed extract respectively), C1 (Negative control), C2 (Positive control, Glibenclamide dose 0.3g/kg) and B (White). 3g/kg) and B (White, reference group). Once the treatments were administered to the study groups, hyperglycemia was induced, for which 30 minutes after the administration of the treatments, a 14g/kg sucrose solution was administered orally. Subsequently, glycemia was assessed using test strips and read on the PRODIGY glycemia meter at 36 minutes, 86 minutes, 6 and 12 hours after sucrose overload. The results were analyzed statistically through the ANOVA test and the 5% Tuckey test, establishing a decrease in glycemia of 44% with the T1 treatment, 54% with the T2 treatment and 21% with the T3 treatment, in relation to the commercial drug which reduces glycemia by 62.4%. It is concluded that the aqueous extract of canaryseed has a hypoglycemic effect, being the best treatment the 70% aqueous extract, besides the histopathological study shows that the canaryseed does not have a toxic effect. It is advisable to carry out more extensive studies since it is a great contribution for new treatments for diabetes.