Efecto Hipolipemiante del Extracto de las Hojas de Frutipan (Artocarpus altilis), en Ratas (Rattus novergicus) con Hiperlipidemia Inducida

Abstract

To test the hypolipidemic effect of Frutipan (Artocarpus Altilis) leaves in rats (Rattus Novergicus) with induced hyperlipidemia. The study was carried out at the Biotherium of ESPOCH. It was studied in vivo in 18 Wistar rats, forming 6 groups of 3 animals each: T1 [0.13 mL Frutipan leaf extract (1.22 mg ß-sitosterol/kg)], T2 [0.29 mL Frutipan leaf extract (2.49 mg ß-sitosterol/kg)], T3 [0.62 mL Frutipan leaf extract (4.87 mg ß-sitosterol/kg)], B [Blank], C+ [Positive Control], C- [Negative Control]. Hyperlipemia was achieved by means of a hyperfat diet raising serum lipids, obtaining in 3 weeks the necessary levels for induction. Treatment of the pathology was continued using Frutipan (Artocarpus altilis) leaf extract and Atorvastatin as a positive control for 7 days, performing periodic determinations of total cholesterol and triglyceride levels by bioreflectometry. The data obtained were analyzed statistically by means of ANOVA one factor with grouped data and Tuckey HSD (Honestly Significant Difference) tests at a confidence interval of 95. The T(3) treatment is the most effective, since there is a reduction of total Cholesterol plasma concentration of 98.33 mg/dL and Triglycerides of 43 mg/dL; with respect to the Positive Control group with a reduction of 131 total Cholesterol plasma concentration of 121.67 mg/dL and Triglycerides of 50 mg/dL. Hypolipidemic activity is attributed to the leaves of Frutipan (Artocarpus altilis). It is recommended to continue with studies to determine other biological activities such as antiasthmatic, antidiarrheal, among others.