Determinación de: Anticuerpos Antinucleares, Anti-DNA, Péptido cíclicos Citrulinado, Proteína C Reactiva, Factor Reumatoide, Antiestreptolisina o para el Diagnóstico de Fiebre Reumática, en Pacientes Pediátricos en Áreas Rurales de la Provincia de Manabí

Abstract

Determinations of: Antinuclear Antibodies, Anti-Dna, Cyclic Citrullinated Peptide, C-Reactive Protein, Rheumatoid Factor, Antistreptolysin O for the diagnosis of Rheumatic Fever, in pediatric patients in rural areas of the Province of Manabi. To pediatric patients with an erythrocyte sedimentation rate greater than 50 mm/hour. In the investigation we will apply the scientific method, all the patients will be evaluated by means of a complete clinical history, clinical diagnosis based on Jones Criteria and laboratory tests, all the tests performed were determined quantitatively and thus we had concrete and validated results. We worked with children from 1 to 11 years old where we performed the serological tests by Turbidimetry: C-Reactive Protein, Rheumatoid Factor, Streptolysin O performed in the Biochemical-turbimetric equipment A15 - Biosystems and the tests of the Autoimmunity tests by Elisa: Nucleic Antibodies, Anti dsDNA and Cyclic Peptide. Citrullinated, performed by two equipments: COMBIWASH Automated Washer - Human and ELISA Reader - Linear. Of a total population of 4156 children, only one pediatric patient had elevated tests such as: PCR, FR, ASTO, ANTI ANA, ANTI dsDNA of the age group 1 - 5 years of the female gender. This result is consistent with the research of Camacho Lovillo, et al. Hospital Virgen del Rocío. Hispalense Institute of Pediatrics. Seville, on infantile RHEUMATIC FEVER indicating that. Studies of rheumatic fever worldwide: in Japan with an annual incidence of 112 cases per 100,000 children under five years of age. In our country, it is estimated that the cumulative annual incidence is similar to that found in the United States (15.1/100,000 in children under 5 years of age). We recommend that this research be a pilot project so that all the provinces of Ecuador have studies with accurate statistics and data to develop preventive and effective measures against autoimmune diseases.