Formulación, elaboración, control de calidad y estudio de estabilidad de una fórmula oficinal de urea solución tópica como coadyuvante en el proceso de hidratación y exfoliación

Abstract

The main objective of this research study was to focus on skin diseases that are among the top five causes of first-level care in Ecuador, and particularly in Chimborazo they account for 30% of this type of care. For this reason, it is important to take care of the health of this organ, through mechanisms such as exfoliation and hydration, properties that have been demonstrated in the urea molecule, which also favors the penetration of topical drugs. Thus, the study aimed to develop a urea-based officinal formulation with moisturizing and exfoliating properties for the skin. The methodology used had an exploratory approach of experimental character through the elaboration of a 15% urea solution, the dependent variable was identified in the moisturizing activity of the ureabased solution, with the analyses that were carried out in the laboratory of Pharmaceutical Technology of the Escuela Superior Politécnica de Chimborazo, and three possible formulations were handled with variation in the concentration of the active principle and other excipients between them, to find the most efficient formulation. Using this methodology, it was determined that the formulation with the best characteristics was B with 15% urea, with a translucent color, semi-liquid appearance, a characteristic aroma of almond essence, a pH close to neutrality (6.7), a density of 1.17 g/ml and the absence of pathogenic microorganisms by current regulations, and its production cost was competent in the national market. Therefore, it is concluded that the 15% urea solution of this research complies with the requirements established in the current regulations and control entities, being a safe product for the user and that it will favor health care.