Formulación y control de calidad de una crema a base de Aristeguietia glutinosa (MATICO) para uso veterinario contra la sarna

Abstract

The purpose of this research was the formulation and quality control of a cream based on Aristeguietia glutinosa (matico) for veterinary use against scabies. To determine the ideal formula, reference was made to the National Formulary of the Pharmacopoeia of the United States of America, the Handbook of Pharmaceutical Excipients fifth edition, the Spanish Standard UNE-EN ISO 29621 for Cosmetics, the Manual for the registration of companies and products for veterinary use and veterinary pharmacology forms. Once the raw material with the best conditions was selected, 9 formulas were prepared, to later choose the one with the best organoleptic, physicochemical, and microbiological characteristics. As a result, it was obtained that when evaluating the physicochemical quality parameters, the pH (acidity index) of the cream was 6.5, considering that the pH of dogs tends to the neutral/alkaline scale; the viscosity was 118,342 cP and the extensibility 506.5, thus showing that the selected formula complied with the quality standards established in the regulations. In the microbiological analysis, no growth of Staphylococcus aureus was detected and the values obtained in total aerobic mesophiles, total count of molds and yeasts did not exceed the established limits. As for its stability, the formula was subjected to a stability chamber for 30 days at controlled temperature and relative humidity, obtaining satisfactory results, since the ideal formula remained stable throughout the trial. It was concluded that the ideal formula contains the necessary and safe ingredients that meet the needs of the formula, complying with the requirements established by the regulatory agencies. It is recommended that in future research, effectiveness and toxicity studies be carried out when working with plant extracts that will be destined for veterinary use.