Estudio del efecto sinérgico de la combinación de amoxicilina y levofloxacina frente a Staphylococcus aureus resistente a meticilina (MRSA)

Abstract

The objective of this research was to study the synergistic effect of the combination of amoxicillin and levofloxacin against methicillin-resistant Staphylococcus aureus (MRSA). The type of research was experimental with a qualitative-quantitative approach and was done in three phases: first, the minimum inhibitory concentration of the combination of amoxicillin and levofloxacin against MRSA was determined, then the efficacy of the synergy of the antibiotic combination was compared, and finally, the efficacy of the combination with respect to linezolid was tested. The results showed that the minimum inhibitory concentration (MIC) of the antibiotics was 8 µg/mL in amoxicillin and 3 µg/mL in levofloxacin, in order to evaluate the synergy of the combination of the drugs, the fractional inhibitory concentration index (FIC) was calculated and when it was 0.1458<0.5, the synergy between the antibiotics was evidenced and finally, when comparing the antibacterial effect with linezolid, it was determined that the MIC of linezolid was 2 µg/mL and the MIC of the combination of amoxicillin and levofloxacin was 2 µg/mL and 3 µg/mL respectively, the MIC of the combination of amoxicillin and levofloxacin was 2 µg/mL and 3 µg/mL respectively. It was concluded that there was a synergistic

effect when combining amoxicillin and levofloxacin, since the antimicrobial effect against MRSA, which is one of the main bacteria causing nosocomial infections at the sanitary level, was enhanced. It is recommended to analyze the synergism of other antibacterial combinations on MRSA bacteria and to use in vivo analysis of pharmacological synergism.