Evaluación de la actividad fotoprotectora de una crema a base de passiflora manicata en la especie cavia porcellus

Abstract

The main objective of this research study was to evaluate the photoprotective activity of a cream based on Passiflora manicata in the species Cavia porcellus, by obtaining the dray extract of the leaves of this species, in this case, flavonoids, as the main photoactive components, for the preparation od a beeler base cream. Through the application in the dermis of the animal, these were exposed to ultraviolet B (UV-B) radiation in the fluorescence chamber, at an approximate wavelength of 300 nm. Subsequently, the level of erythema on the animal's skin was measured through the mexameter, a process that was repeated in the three formulations prepared at different concentrations, which were: 0.2, 0.3, 0.4, percent of Passiflora manicata Active Principle and each one of these formulation was applied in 5 control groups, each one made up of five experimental animals called: control group, placebo group, creams at their three concentrations. With a significant result within the 3 formulations, for the 0.2% formulation compares to the control group (Octyl-methoxycinnamate with a sun protection factor (SPF) of 0.2 with 40 min protection), it gave a sun protection factor of 1.56 with a time of protection of 30 min of the effectiveness of the cream, due to the presence of flavonoids and other metabolites that have an antioxidant and photoprotective effect for the skin. After obtaining the extract and preparing the formulation and applying them to the animals, the possibility od therapeutic alternatives was expanded in the face of the growing wave of skin conditions due to the high levels of radiation to which we are exposed daily. For this reason, it is recommended to continue developing clinical studies based on this species, for a possible application in humans.