Tamizaje fitoquímico y actividad antiinflamatoria de Jungia rugosa Less para la elaboración de un ungüento

Abstract

In the present research, the problem of evaluating the anti-inflammatory activity of the puna matico (Jungia rugosa Less) addressed to perform phytochemical screening and evaluate the anti-inflammatory activity of the puna matico (Jungia rugosa Less) for the elaboration of an ointment. The methodology involved several steps: the raw material obtained from stems and leaves of the matico, which were dried, crushed, and packaged with different solvents. Using phytochemical screening tests, secondary metabolites were identified in the extracts, highlighting the alcoholic extract of the leaves for its higher content. Using Gas Chromatography coupled with Mass Spectrometry, the composition of flavonoids in the alcoholic extract approximates. Through the method of maceration in alcohol, the active ingredient for producing an anti-inflammatory ointment is obtained. The results showed that the cream made from the alcoholic extract of matico leaves has anti-inflammatory activity, evidenced by the reduction of carrageenan-induced edema in animal models. Including additional components in the formulation ensured the stability and topical applicability of the ointment, reinforcing its therapeutic potential. Overall, these findings highlight the viability of puna matico as a source of anti-inflammatory principles for the development of topical products.