Formulación y control de calidad de crema en barra con propiedades antibacterianas a base de Rosmarinus officinalis y Myrcianthes hallii

Abstract

The aim of this work was to formulate a stick cream with antibacterial properties based on Myrcianthes hallii (Myrtle) and Rosmarinus officinalis L. (Rosemary). Firstly a quality control of the plant species and extracts was carried out, then in the phytochemical screening, the presence of alkaloids, quinones, flavonoids was identified, while in the quantification of metabolites, 1 874,892 mg Eq GAE/100 g of phenols and 3 256,568 mg Eq Q/100 g of flavonoids was obtained for rosemary and for myrtle 4 972,254 mg Eq GAE/100 g of phenols and 1 283,546 mg Eq Q/100 g of flavonoids, responsible for the antibacterial activity. For the formulation of the creams, the modification of parameters was considered, such as: alcoholic strength of the extracts, quantity and type of excipients. In addition, the antibacterial activity of the extracts against Staphylococcus aureus was evaluated, these extracts were: the hydroalcoholic, concentrated and lyophilized, which formed halos of 20, 24 and 25 mm, respectively, compared to a positive control of cefoxitin with 27 mm. As a result, the 70% lyophilized extract presented better antibacterial activity, however, it was not used in the cream, due to the change of color from white to greenish. Nine formulations were made, the ninth was the best with the mixture of 70% hydroalcoholic extracts, complying with the “Instructivo externo código IE-C.2.2-COS-02, de las especificaciones fisicoquímicas, organolépticas y microbiológicas para los productos cosméticos de bajo riesgo, especificado por el ARCSA” and labeling according to NTE INEN 2867, on the other hand, the accelerated stability study was carried out on the finished product. Finally, it is recommended to study the antibacterial effectiveness of the extracts of M. hallii and R. officinalis against S. aureus for application in phytocosmetics and medicines.