Evaluación de la Actividad Antiinflamatoria del Extractos de Verdolaga (Portulaca oleracea) en Ratas (Rattus novergicus) con Edema Inducido por Carragenina en el Bioterio ESPOCH.

Abstract

"This work's goal was to compare the anti-inflammatory activity from the ethanolic extract of the purslane (Portulaca oleracea) leaves, stems and seeds. There were applied different dosages and treatments on rats with to find the most adequate to probe their effectiveness as an alternative to antiinflammatory drugs because there is a trend to use natural products. The antiinflammatory effect was measured on 15 albino rats which were injected with carragcenanin the foot area producing inflammation. They were undergone to 5 treatments, being TI a control group that only had distilled water as a vehicle, T2 is a group that received the antiinlammatory indomethacin, and the other groups were treated with the extracis orally using a cannula. T3 had an amount of the extract of 250mg/Kg, Tá an amount of 350mg/Kg, and TS had S00mg/Kg. There were measured all the volumes of inflammation from twelve o'clock at midnight until seven ""clock in the morning. It was found a diminishing on the speed of an edema formation. There were calculated inflammation percentages every hour and it was determined that here was a significant statistic difference between the treated groups and the control groups (p<0,01) According to the antiinflammatory effect obtained in an increasing way for the results, they showed this: TS>T4>T3 . The ethaonolic extract with dosages of 500mg/Kg showed an similar effectiveness to the indomethacin until 5 hours. Once that time gone by became to lose the effect, that's why it required a new administration. Its different from the indomethacin that was given once, as a result it showed an inferior activity to this drug. It is recommended to perform an study for secondary metabolites presented in this species, such as alkalds, lavonoids, saponins,tannins and catechins."