Revisión científica del uso de hidrogeles como sistemas de liberación controlada de fármacos en cáncer de mama

Abstract

The purpose of this research was to review publications on the use of hydrogels as controlled drug release systems in breast cancer. Through an exhaustive bibliographic search, scientific articles were compiled that more than 60% correspond to the last 5 years, in different high-impact academic search engines such as: ScienceDirect, Springer, Taylor and Francis, etc. The web search was based on keywords in English: hydrogels and breast cancer, and in Spanish: hydrogels for drug delivery and hydrogels in breast cancer. The fifty-one selected publications have relevant information about the characteristics and types of hydrogels, drugs used for encapsulation and release, the mechanism of action of these systems when entering the body and the effects produced towards the different cell lines of the mammary tissue. Therefore, it was shown that hydrogels combined with the different drugs have a potential use as controlled release systems in breast cancer, helping to improve the quality of patients life, reducing significant side effects compared to conventional chemotherapy.