Identificación de los resultados negativos asociados al uso de sulfato de magnesio en enfermedad hipertensiva gestacional en pacientes hospitalizadas del Hospital Gineco Obstétrico Isidro Ayora.

Abstract

The present research project had as objective to identify the negative results (RNM) associated with the management pharmacotherapeutic of magnesium sulphate in the hypertensive disease of pregnancy, in patients hospitalized in the Gyneco-obstetric Hospital Isidro Ayora during the period May - July 2019. The study was conducted in 92 patients with a positive diagnosis of preeclampsia (PE), with the information on admission data and the pharmacotherapeutic profile, pharmacotherapeutic follow-up (PFT) was used with the Workup method. The analysis started with the assessment of the situation status until the identification of the possible RNM associated with the therapy, additionally in the databases Drugs, iDoctus and Medscape identifies the pharmacological interactions (PI) and the manifested severity; for the causality analysis, the Naranjo algorithm was used, as well as the analysis of medication-related problems (MRP), Adverse drug reactions (ADR) and subsequent verification of RNM associated with the use of magnesium sulfate. With the controlled values of the pharmacotherapeutic follow-up profile, the analysis of the variables was processed using the Excel and SPSS program with the binary logistic regression models and CHI2 test to establish the association between medication errors and the manifestations RAMs, in addition identified the most relevant risk factors (RF). The results indicated that 100% of the population and with a manifestation of 64% the main RNM were due to: safety (87%), need (8%) and effectiveness (5%) by the MRP: IF (44%), ADR (35%), Problems related to the use of medications (20%) and contraindications (1%), greater association with tachycardia and hypoventilation RAMS and RF related to gestational age, personal history of PE and gestational hypertension in addition to multiparity. Concluding that the events were manifested preventable through health education and professional practical correction, therefore the use of tools that facilitate the identification, prevention and treatment in current and future cases is recommended.