Evaluación del uso de antibióticos betalactámicos en el Servicio de Hospitalización del Hospital General Andino en el periodo Enero 2017 a Julio de 2018.

Abstract

The purpose of this work is to evaluate the use of beta-lactam antibiotics in the hospitalization service of de Andean General Hospital of Chimborazo in the period ranging from January 2017 to July 2018 , by reviewing medical histories and then filling out records with the date collected. A descriptive, retrospective, cross–sectional and non-experimental study is carried out at the Andean General hospital of Chimborazo, 199 medical records of patients of both sexes hospitalized in the departments of Internal Medicine, Surgery and Gynecology are included, having as study variables gender, age, diagnosis of admission, prescribed antibiotics, dose, route of administration, length of therapy, drug interactions, therapeutic protocol and problems related to medications. The results reveled that the most prescribed antibiotics in this service were: beta-lactams such as ceftriaxone in (46, 42 %), ampicillin + sulbactam in (20.75 %), cefazolina in (12.85%) and cephalexin (9.81 %), The area with the highest consumption of antibiotics was internal medicine, followed by surgery and gynecology. In addition 39 drug interactions with antibiotics were identified, most of these with ceftriaxone: 58 cases of PRM were detected,with PRM 6 being the most frequent (67.24 %), followed by PRM 2 (31.03 %) and PRM 5 (1.72% ) . The most prescribed antibiotics are ceftriaxone (46.42 %), the same ones that in 71.86 % were in concordance with the Therapeutic Protocols of the MSP . 39 drug interactions with antibiotics were detected,among the principal is ceftriaxone with aminoglycosides such as amikacin and gentamicin that increases the bactericidal effect,58 cases of PRM were detected ,with PRM 6 being the most frequent (67.24%) which causes an increase inserum concentration of some antibiotics and potentiates their toxicity in the patient. Therefore, it is recommended to carry out complementary studies.