Formulación de un protector solar a base de Passiflora manicata (Juss.) Pers.

Abstract

The objective of the present degree work was to formulate a sun protect based on Passiflora Manicata (Juss.) Pers. A phytochemical screening performed for the qualitative identification of the metabolites present in the extract. The dry extract obtained by maceration and subsequent concentration in a suitable rotavapor. The quantification of phenols and flavonoids was carried out employing colorimetric methods. For the determination of the SPF, solutions of 20, 100, 200, 500 and 1000ppm of the dry extract were prepared, and the absorbance in the spectrophotometer were read in a range of 290 to 32 nm with an interval of 5 nm; subsequently, the Mansur equation applied. For the formulations only allowed ingredients were used based on limits established by the FDA. Then, the quality control of the formulations was carried out, including the microbiological analysis of the formulation with the best performance and the label elaborated according to the NTE INEN 2867 Standard. In the phytochemical screening, they identified metabolites as triterpenes, steroids, lactones coumarins, reducing sugars, phenolic compounds, and flavonoids, among others. The content of total phenolic in the dry extract was 240.00 10mg EAC / g extract, whereas of flavonoids 259.68 3.69 mg EQ / g extract was obtained. Photo protective activity the extract obtained significant values, where determined that the FPS 1000 ppm was 42. Formulation 1 presented excellent characteristics keep the FPS 42. It was established that the best formulation based Passiflora manicata (Juss.) Pers. it was the one, the same that comply with the limits of acceptability for microbiological parameters. It is recommended that studies hypoallergenic, no comedogenicity and toxicology to ensure product safety.